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The lesson: If you have something important to do the next morning, consider staying inside the bar while your friends go out to smoke

Smoking is particularly likely to stain the upper front teeth because of the way people smoke

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Sample size calculation The required sample size was estimated to be 363 (min 272) based on the prevalence of IBS in the general population being estimated to be 13% with an estimated error of 4%, Type 1 error (alpha) 5% (two-tailed), power 95%, and allowing for a 25% dropout rate

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